The SBF2 Polyclonal Antibody (PAC046722) is a valuable tool for researchers studying SBF2, a protein involved in cellular functions related to cell growth and proliferation. This antibody, produced using rabbits as the host, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SBF2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in cell biology and cancer research.
SBF2 plays a crucial role in regulating cell division and growth, making it a key player in processes like tumorigenesis and development. Its involvement in these cellular mechanisms makes it a promising target for research aimed at understanding and potentially treating diseases such as cancer. By unraveling the functions of SBF2, researchers can gain valuable insights that may lead to the development of targeted therapies with potential applications in the fields of oncology and regenerative medicine.
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO46722 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46722 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO46722 at dilution of 1:100.
Background:
Guanine nucleotide exchange factor (GEF) which may activate RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Synonyms:
Myotubularin-related protein 13 (SET-binding factor 2), SBF2, CMT4B2 KIAA1766 MTMR13
UniProt Protein Function:
MTMR13: a widely expressed pseudophosphatase and peripheral membrane guanine nucleotide exchange factor (GEF) that activates RAB28, a small G protein of the Rab subfamily. Promotes Rab21 GTPase activation associated with PI(3)P endosomes. Coordinates PIP3 and Rab21 regulation in an endosomal pathway. Functions together with Mtm and Rab21, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation and to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Interacts with MTMR2. Defects in MTMR13 are the cause of Charcot-Marie-Tooth disease type 4B2 (CMT4B2). CMT4B2 is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, RabChromosomal Location of Human Ortholog: 11p15.4Cellular Component: membraneMolecular Function: protein binding; Rab guanyl-nucleotide exchange factor activityDisease: Charcot-marie-tooth Disease, Type 4b2
UniProt Protein Details:
NCBI Summary:
This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008]
