The Anti-SBDS Antibody (CAB0796) is a polyclonal antibody designed for research involving the SBDS protein, which is essential for ribosomal RNA processing and maturation, making it a key player in ribosome biogenesis. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot and immunohistochemistry applications.SBDS mutations have been linked to Shwachman-Diamond syndrome, a rare genetic disorder characterized by bone marrow failure, exocrine pancreatic insufficiency, and skeletal abnormalities.
Research on SBDS is crucial for understanding the molecular mechanisms underlying this syndrome and developing potential treatments.The Anti-SBDS Antibody enables researchers to detect and analyze SBDS protein expression in various cell types, allowing for in-depth studies on ribosome biogenesis, RNA processing, and the impact of SBDS mutations on cellular function. This antibody is an invaluable tool for investigations in genetics, cell biology, and developmental biology related to ribosomal function and disease mechanisms.
Product Name:
SBDS Rabbit Monoclonal Antibody
SKU:
CAB0796
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 151-250 of human SBDS (NP_057122.2).
This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located.
Purification Method:
Affinity purification
Gene ID:
51119
Clone Number:
ARC2539
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SBDS antibody (CAB0796) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
