The SAV1 Polyclonal Antibody (CAB9980) is a valuable tool for researchers studying SAV1, a key regulator of the Hippo signaling pathway involved in cell growth and proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By binding to the SAV1 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating investigations in developmental biology and cancer research.SAV1, also known as Salvador homolog 1, plays a crucial role in controlling organ size and tissue regeneration by modulating cell proliferation and apoptosis.
Dysregulation of the Hippo pathway, where SAV1 is a key component, has been implicated in various diseases, including cancer. Therefore, understanding the function of SAV1 is essential for unraveling the mechanisms underlying tumorigenesis and potential therapeutic targets for cancer treatment.With its high reactivity and specificity, the SAV1 Polyclonal Antibody (CAB9980) is a reliable tool for researchers seeking to explore the role of SAV1 in normal physiological processes and disease states, ultimately contributing to advancements in the field of molecular biology and therapeutic development.
Product Name:
SAV1 Rabbit Polyclonal Antibody
SKU:
CAB9980
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 199-383 of human SAV1 (NP_068590.1).
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Purification Method:
Affinity purification
Gene ID:
60485
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SAV1 antibody (CAB9980) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
