SAV1 Rabbit Polyclonal Antibody (CAB9980)
- SKU:
- CAB9980
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SAV1 Rabbit Polyclonal Antibody |
SKU: | CAB9980 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-383 of human SAV1 (NP_068590.1). |
Sequence: | LPLP PGWS VDWT MRGR KYYI DHNT NTTH WSHP LERE GLPP GWER VESS EFGT YYVD HTNK KAQY RHPC APSV PRYD QPPP VTYQ PQQT ERNQ SLLV PANP YHTA EIPD WLQV YARA PVKY DHIL KWEL FQLA DLDT YQGM LKLL FMKE LEQI VKMY EAYR QALL TELE NRKQ RQQW YAQQ HGKN F |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:4000 |
Synonyms: | SAV; WW45; WWP4; SAV1 |
Positive Sample: | HeLa,SKOV3,SW480 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Purification Method: | Affinity purification |
Gene ID: | 60485 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |