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Anti-SAT1 Antibody (CAB2506)

SKU:
CAB2506
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

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Anti-SAT1 Antibody (CAB2506)

The SAT1 Polyclonal Antibody (CAB2506) is a valuable tool for researchers studying the SAT1 gene, which encodes for the enzyme spermidine/spermine N1-acetyltransferase. This enzyme plays a crucial role in polyamine metabolism, which is involved in cell proliferation, differentiation, and apoptosis.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the SAT1 protein, researchers can effectively detect and analyze its expression in various cell types.The SAT1 Polyclonal Antibody is particularly useful for studies in cancer research, as dysregulation of polyamine metabolism has been linked to tumorigenesis and tumor progression.

By understanding the role of SAT1 in these processes, researchers can potentially identify new therapeutic targets for cancer treatment.Overall, the SAT1 Polyclonal Antibody is a valuable tool for researchers investigating the function of the SAT1 gene and its implications in various diseases, paving the way for advancements in personalized medicine and targeted therapies.

Antibody Name:Anti-SAT1 Antibody
Antibody SKU:CAB2506
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-171 of human SAT1 (NP_002961.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-171 of human SAT1 (NP_002961.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAKF VIRP ATAA DCSD ILRL IKEL AKYE YMEE QVIL TEKD LLED GFGE HPFY HCLV AEVP KEHW TPEG HSIV GFAM YYFT YDPW IGKL LYLE DFFV MSDY RGFG IGSE ILKN LSQV AMRC RCSS MHFL VAEW NEPS INFY KRRG ASDL SSEE GWRL FKID KEYL LKMA TEE
Gene ID:6303
Uniprot:P21673
Cellular Location:Cytoplasm
Calculated MW:20kDa
Observed MW:20kDa
Synonyms:DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1, SAT1
Background:The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.
UniProt Protein Function:SAT: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX). A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Belongs to the acetyltransferase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - arginine and proline; EC 2.3.1.57; Acetyltransferase

Chromosomal Location of Human Ortholog: Xp22.1

Cellular Component: intracellular; cytosol

Molecular Function:protein binding; diamine N-acetyltransferase activity; spermidine binding

Biological Process: spermidine acetylation; polyamine biosynthetic process; angiogenesis; putrescine catabolic process; polyamine metabolic process; regulation of cell proliferation

Disease: Keratosis Follicularis Spinulosa Decalvans, X-linked

NCBI Summary:The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:P21673
NCBI GenInfo Identifier:114322
NCBI Gene ID:6303
NCBI Accession:P21673.1
UniProt Related Accession:P21673
Molecular Weight:171
NCBI Full Name:Diamine acetyltransferase 1
NCBI Synonym Full Names:spermidine/spermine N1-acetyltransferase 1
NCBI Official Symbol:SAT1  
NCBI Official Synonym Symbols:SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1  
NCBI Protein Information:diamine acetyltransferase 1; putrescine acetyltransferase; diamine N-acetyltransferase 1; polyamine N-acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha
UniProt Protein Name:Diamine acetyltransferase 1
UniProt Synonym Protein Names:Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT; SSAT-1
Protein Family:Serine acetyltransferase
UniProt Gene Name:SAT1  
UniProt Entry Name:SAT1_HUMAN
Anti-SAT1 Antibody (CAB2506)Western blot analysis of extracts of THP-1 cells, using SAT1 antibody (CAB2506) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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