The SASH1 Polyclonal Antibody (CAB15248) is specifically designed for research involving SASH1, a key protein in cell signaling pathways and tumor suppression. This antibody, produced in rabbits, is highly sensitive and specific for detecting SASH1 in human samples, making it a valuable tool for cancer research and understanding cellular signaling mechanisms.SASH1, also known as SAM and SH3 domain-containing protein 1, is involved in multiple cellular processes such as cell proliferation, migration, and apoptosis. Its dysregulation has been linked to various cancers, making it a potential therapeutic target for cancer treatment.
This antibody has been validated for use in Western blot applications, enabling researchers to detect and analyze the expression of SASH1 in different cell types.By utilizing the SASH1 Polyclonal Antibody in their studies, researchers can gain valuable insights into the role of SASH1 in cancer development and progression, as well as its potential as a therapeutic target. Understanding the molecular mechanisms of SASH1 can lead to the development of novel treatment strategies for cancer patients.
Product Name:
SASH1 Rabbit Polyclonal Antibody
SKU:
CAB15248
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SASH1 (NP_056093.3).
This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients.
Purification Method:
Affinity purification
Gene ID:
23328
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SASH1 Rabbit pAb (CAB15248) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
