The SART1 Polyclonal Antibody (CAB8569) is a valuable tool for research involving SART1, a protein involved in RNA splicing and mRNA processing. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the SART1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cancer research.SART1, also known as squamous cell carcinoma antigen recognized by T cells, plays a crucial role in the regulation of gene expression and the maintenance of genomic stability.
Its involvement in RNA metabolism and cell growth processes makes it a key player in the development and progression of cancer. Research into SART1 can provide insights into the molecular mechanisms underlying various types of cancer and may offer potential targets for therapeutic intervention.Overall, the SART1 Polyclonal Antibody offers researchers a reliable tool for investigating the functions and interactions of the SART1 protein in normal and disease states, ultimately contributing to advancements in the understanding and treatment of cancer and other related disorders.
Product Name:
SART1 Rabbit Polyclonal Antibody
SKU:
CAB8569
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human SART1 (NP_005137.1).
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
Purification Method:
Affinity purification
Gene ID:
9092
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SART1 Rabbit pAb (CAB8569) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
