The Sarcospan Polyclonal Antibody (CAB12191) is a valuable tool for researchers working with sarcospan, a transmembrane protein that plays a key role in muscle cell membrane stability and function. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.Sarcospan is a critical component of the dystrophin-glycoprotein complex, which is essential for maintaining the structural integrity of muscle fibers. Dysfunction of sarcospan has been implicated in the pathogenesis of muscular dystrophies and other muscle disorders, making it a promising target for therapeutic interventions.
By specifically binding to the sarcospan protein, this polyclonal antibody enables researchers to detect and analyze sarcospan expression in different cell types, providing valuable insights into its role in muscle biology and disease. This antibody is an indispensable tool for studies aimed at investigating the function of sarcospan and developing novel treatments for muscle-related disorders.
Product Name:
SSPN Rabbit Polyclonal Antibody
SKU:
CAB12191
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SSPN (NP_005077.2).
This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
8082
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SSPN Rabbit pAb (CAB12191) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
