UniProt Protein Function: | TMEM66: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Belongs to the SARAF family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 8p12Cellular Component: integral to endoplasmic reticulum membraneMolecular Function: protein binding |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q96BY9 |
NCBI GenInfo Identifier: | 74731293 |
NCBI Gene ID: | 51669 |
NCBI Accession: | Q96BY9.1 |
UniProt Secondary Accession: | Q96BY9,Q53HE8, Q9UNZ3, Q9Y683, B3KQQ4, B7Z9J1, D3DSU7 H9MHJ8, H9MHJ9 |
UniProt Related Accession: | Q96BY9 |
Molecular Weight: | 17,876 Da |
NCBI Full Name: | Store-operated calcium entry-associated regulatory factor |
NCBI Synonym Full Names: | store-operated calcium entry associated regulatory factor |
NCBI Official Symbol: | SARAFÂ Â |
NCBI Official Synonym Symbols: | XTP3; FOAP-7; TMEM66; HSPC035Â Â |
NCBI Protein Information: | store-operated calcium entry-associated regulatory factor |
UniProt Protein Name: | Store-operated calcium entry-associated regulatory factor |
UniProt Synonym Protein Names: | HBV X-transactivated gene 3 protein; HBV XAg-transactivated protein 3; Protein FOAP-7; Transmembrane protein 66 |
Protein Family: | Store-operated calcium entry-associated regulatory factor |
UniProt Gene Name: | SARAFÂ Â |
UniProt Entry Name: | SARAF_HUMAN |