The SAP18 Polyclonal Antibody (CAB4397) is a vital tool for researchers studying SAP18, a protein involved in chromatin remodeling and transcriptional regulation processes. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it a valuable asset in studies involving protein expression analysis using techniques such as Western blotting.SAP18, a component of the Sin3 histone deacetylase corepressor complex, plays a crucial role in gene regulation by modulating chromatin structure and transcriptional activity. Its involvement in cellular processes such as cell proliferation, differentiation, and DNA repair makes it a key player in various biological pathways.
The SAP18 Polyclonal Antibody enables researchers to detect and analyze SAP18 protein levels in different cell types, facilitating a better understanding of its function in cell physiology and disease development.Researchers focusing on gene expression regulation, epigenetics, and cancer biology will benefit from using the SAP18 Polyclonal Antibody in their experiments. By investigating SAP18's molecular mechanisms and interactions with other regulatory proteins, scientists can unravel its implications in diseases like cancer and potentially identify new therapeutic targets for intervention.
Product Name:
SAP18 Rabbit Polyclonal Antibody
SKU:
CAB4397
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_005861.2).
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
10284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from SW480 cells, using SAP18 Rabbit pAb (CAB4397) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
