The SAP130 Polyclonal Antibody (CAB13897) is a valuable tool for researchers studying SAP130, a protein involved in various cellular processes, including RNA splicing and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By targeting the SAP130 protein, researchers can effectively detect and analyze its expression in different cell types, providing insights into its role in biological pathways.SAP130 is a critical component of the splicing factor SF3b complex, which is involved in pre-mRNA splicing and spliceosome assembly. Dysregulation of SAP130 has been linked to various diseases, including cancer and neurodevelopmental disorders, highlighting its importance in cellular function.
By studying SAP130 using this antibody, researchers can gain a deeper understanding of its function and potential implications in disease pathology, paving the way for the development of targeted therapies.Overall, the SAP130 Polyclonal Antibody is a valuable tool for researchers interested in investigating the role of SAP130 in cellular processes and disease mechanisms. Its high specificity and sensitivity make it an ideal choice for studies in molecular biology, cancer research, and neurobiology, providing valuable insights into the complex functions of this important protein.
Product Name:
SAP130 Rabbit Polyclonal Antibody
SKU:
CAB13897
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 819-1048 of human SAP130 (NP_078821.2).
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).
Purification Method:
Affinity purification
Gene ID:
79595
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using SAP130 Rabbit pAb (CAB13897) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
