The SAMSN1 Polyclonal Antibody (PAC041974) is a powerful tool for researchers studying SAMSN1, a novel adaptor molecule involved in immune signaling pathways. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By targeting the SAMSN1 protein, this antibody enables researchers to investigate the role of SAMSN1 in various cellular processes, making it an essential reagent for studies in immunology and cancer research.SAMSN1, also known as SH-3 domain-containing SAM domain protein, is a key player in modulating immune responses by regulating signaling cascades involved in cell activation and proliferation.
Its involvement in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of SAMSN1 is crucial for developing targeted therapies that can potentially manipulate immune responses to treat these diseases effectively.
Antibody Name:
SAMSN1 Antibody (PACO41974)
Antibody SKU:
PACO41974
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human SAM domain-containing protein SAMSN-1 protein (1-373AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO41974 at dilution of 1:100.
Background:
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
Synonyms:
SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein), SAMSN1, HACS1
UniProt Protein Function:
SAMSN1: an adaptor and scaffold protein containing an SH3 and a SAM (sterile alpha motif) domain. Its expression is induced by B cell activation signals. Two alternatively spliced isoforms have been described.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 21q11Cellular Component: ruffle; cytosol; nucleusMolecular Function: phosphotyrosine bindingBiological Process: negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of adaptive immune response; negative regulation of B cell activation
UniProt Protein Details:
NCBI Summary:
SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]
SAM domain, SH3 domain and nuclear localization signals 1
NCBI Official Symbol:
SAMSN1Â Â
NCBI Official Synonym Symbols:
SLy2; HACS1; NASH1; SASH2; SH3D6BÂ Â
NCBI Protein Information:
SAM domain-containing protein SAMSN-1
UniProt Protein Name:
SAM domain-containing protein SAMSN-1
UniProt Synonym Protein Names:
Hematopoietic adaptor containing SH3 and SAM domains 1; Nash1; SAM domain, SH3 domain and nuclear localization signals protein 1; SH3-SAM adaptor protein
