Samhd1 Antibody (PACO29744)
- SKU:
- PACO29744
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Samhd1 Antibody (PACO29744)
The SAMHD1 Polyclonal Antibody (PAC029744) is a valuable tool for researchers studying SAMHD1, a protein involved in nucleic acid metabolism and immune responses. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to SAMHD1, facilitating the detection and analysis of this protein in various cell types, making it ideal for investigations in immunology and cancer research.SAMHD1 is known for its role in controlling the levels of nucleotides in cells, thereby influencing processes such as DNA replication, repair, and antiviral immune responses.
Dysregulation of SAMHD1 has been linked to various diseases, including cancer and autoimmune disorders, highlighting its importance in maintaining cellular homeostasis and immune function. Research into SAMHD1 could lead to the development of novel therapeutic strategies for these diseases by targeting this crucial protein.
| Antibody Name: | Samhd1 Antibody (PACO29744) |
| Antibody SKU: | PACO29744 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 protein (426-657AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Samhd1 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 76, 75 kDa Observed band size: 76 kDa . |
| Background: | Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-α signaling (By similarity). |
| Synonyms: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Interferon-gamma-inducible protein Mg11) (SAM domain and HD domain-containing protein 1), Samhd1, Mg11 |
| UniProt Protein Function: | SAMHD1: a protein induced by interferon gamma.Protein type: EC 3.1.4.-Chromosomal Location of Human Ortholog: 2|2 H1Cellular Component: nucleoplasm; nucleus; plasma membraneMolecular Function: dGTP binding; dGTPase activity; nucleic acid binding; ribonuclease activity; RNA binding; triphosphoric monoester hydrolase activity; zinc ion bindingBiological Process: dATP catabolic process; defense response to virus; dGTP catabolic process; protein homotetramerization; regulation of innate immune response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q60710 |
| NCBI GenInfo Identifier: | 213418079 |
| NCBI Gene ID: | 56045 |
| NCBI Accession: | NP_001132992.1 |
| UniProt Secondary Accession: | Q60710,Q3U5X2, Q543A4, Q91VK8 |
| UniProt Related Accession: | Q60710 |
| Molecular Weight: | 30.7kD |
| NCBI Full Name: | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 2 |
| NCBI Synonym Full Names: | SAM domain and HD domain, 1 |
| NCBI Official Symbol: | Samhd1Â Â |
| NCBI Official Synonym Symbols: | Mg11; E330031J07Rik  |
| NCBI Protein Information: | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
| UniProt Protein Name: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
| UniProt Synonym Protein Names: | Interferon-gamma-inducible protein Mg11; SAM domain and HD domain-containing protein 1 |
| Protein Family: | |
| UniProt Gene Name: | Samhd1Â Â |
| UniProt Entry Name: |
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