The SAMD4A Polyclonal Antibody (PAC020385) is a valuable tool for researchers studying SAMD4A, a protein involved in RNA metabolism and regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SAMD4A protein, this antibody allows for the detection and analysis of SAMD4A in various cell types, making it ideal for investigations in molecular biology and RNA-related research.SAMD4A, also known as sterile alpha motif domain-containing protein 4A, plays a crucial role in post-transcriptional regulation of gene expression by interacting with RNA molecules.
Dysregulation of SAMD4A has been implicated in various diseases, including cancer and neurological disorders. Therefore, studying the function of SAMD4A is important for gaining insights into RNA metabolism and potential therapeutic targets in these conditions.Overall, the SAMD4A Polyclonal Antibody is a reliable tool for researchers seeking to investigate the role of SAMD4A in gene expression regulation and its implications in disease pathology. Its high specificity and reactivity make it a valuable asset for advancing scientific knowledge in the field of molecular biology.
Antibody Name:
SAMD4A Antibody (PACO20385)
Antibody SKU:
PACO20385
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SAMD4A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20385(SAMD4A Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20385(SAMD4A Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Sterile α motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein.
Synonyms:
sterile α motif domain containing 4A
UniProt Protein Function:
Function: Acts as a translational repressor of SRE-containing messengers. Ref.6Subcellular location: Cytoplasm. Cell projection › dendrite By similarity. Cell junction › synapse › synaptosome By similarity. Note: Enriched in synaptoneurosomes By similarity. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. Ref.6Sequence similarities: Belongs to the SMAUG family.Contains 1 SAM (sterile alpha motif) domain.Sequence caution: The sequence AAH57838.1 differs from that shown. Reason: Intron retention.The sequence AAP97302.1 differs from that shown. Reason: Intron retention.
UniProt Protein Details:
NCBI Summary:
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]
