The SAFB Polyclonal Antibody (CAB7927) is a valuable tool for researchers studying the SAFB protein, a critical regulator of gene expression and RNA processing. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting SAFB in human samples, making it ideal for use in various research applications, including Western blot analysis.SAFB, also known as scaffold attachment factor B, plays a crucial role in modulating gene expression by directly interacting with DNA and RNA molecules. Its involvement in chromatin organization and transcriptional regulation makes it an important player in cellular processes such as DNA repair, RNA splicing, and gene silencing.
The SAFB Polyclonal Antibody enables researchers to investigate the function and localization of SAFB in different cell types, providing insights into its role in development, cancer, and other diseases.By utilizing the SAFB Polyclonal Antibody, researchers can deepen their understanding of the molecular mechanisms underlying gene regulation and RNA processing, paving the way for the development of targeted therapies for diseases associated with dysregulated gene expression. This antibody is a valuable resource for studies in molecular biology, oncology, and developmental biology, facilitating impactful discoveries in the field of life sciences.
Product Name:
SAFB Rabbit Polyclonal Antibody
SKU:
CAB7927
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SAFB (NP_001188267.1).
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6294
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SAFB Rabbit pAb (CAB7927) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
