SAFB Rabbit Polyclonal Antibody (CAB7927)
- SKU:
- CAB7927
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | SAFB Rabbit Polyclonal Antibody |
SKU: | CAB7927 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SAFB (NP_001188267.1). |
Sequence: | MAET LSGL GDSG AAGA AALS SASS ETGT RRLS DLRV IDLR AELR KRNV DSSG NKSV LMER LKKA IEDE GGNP DEIE ITSE GNKK TSKR SSKG RKPE EEGV EDNG LEEN SGDG QEDV ETSL ENLQ DIDI MDIS VLDE AEID NGSV ADCV EDDD ADNL QESL SDSR ELVE GEMK ELPE QLQE HAIE DKET INNL DTSS SDFT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1; SAFB |
Positive Sample: | U-87MG,DU145,NIH/3T3,Mouse brain,Mouse lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 103kDa |
Observed MW: | 155kDa |
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 6294 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |