The SAA1 Polyclonal Antibody (CAB1655) offered by Assay Genie is a valuable tool for researchers studying the Serum Amyloid A1 (SAA1) protein, a major acute-phase reactant secreted in response to inflammation. This antibody, produced in rabbits, is highly specific for human SAA1 and has been validated for use in Western blot applications, enabling accurate detection and analysis of SAA1 levels in various biological samples.SAA1 is a key player in the acute-phase response, promoting inflammation and serving as a biomarker for a variety of inflammatory conditions, including infections, autoimmune diseases, and cancer.
Research into the regulation and function of SAA1 is essential for understanding the pathogenesis of these diseases and developing targeted therapies.By utilizing the SAA1 Polyclonal Antibody, researchers can gain valuable insights into the role of SAA1 in inflammation and disease, opening up new possibilities for diagnostic and therapeutic advancements. This antibody is an essential tool for studies in immunology, oncology, and inflammatory disorders, providing a reliable means of investigating the functions of SAA1 in health and disease.
Product Name:
SAA1 Rabbit Polyclonal Antibody
SKU:
CAB1655
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-122 of human SAA1 (NP_000322.2).
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
6288
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of SW480 cells, using SAA1 antibody (CAB1655) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
