The SAA1 Polyclonal Antibody (CAB14553) is specifically designed for research involving Serum Amyloid A1 (SAA1), a major acute-phase reactant protein associated with inflammation and various diseases. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the SAA1 protein, it enables accurate detection and analysis in different cell types, making it a valuable tool for studies in immunology, inflammation, and disease research.SAA1, a member of the SAA family of proteins, is known for its role in the acute-phase response to inflammation and infection.
Elevated levels of SAA1 are associated with various conditions, including inflammatory diseases, cardiovascular diseases, and cancer. Understanding the function and regulation of SAA1 is crucial for elucidating its role in disease pathogenesis and identifying potential therapeutic targets.Overall, the SAA1 Polyclonal Antibody is a reliable tool for researchers investigating the role of SAA1 in inflammation, immunity, and disease, providing valuable insights into the mechanisms underlying these processes and potential therapeutic interventions.
Product Name:
SAA1 Rabbit Polyclonal Antibody
SKU:
CAB14553
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SAA1 (NP_000322.2).
Sequence:
MKLL TGLV FCSL VLGV SSRS FFSF LGEA FDGA RDMW RAYS DMRE ANYI GSDK YFHA RGNY DAAK RGPG GAWA AEVI SDAR ENIQ RFFG HGAE DSLA DQAA
Tested Applications:
WBIHC-PELISA
Recommended Dilution:
WB,1:500 - 1:2000 IHC-P,1:100 - 1:200
Synonyms:
SAA; PIG4; SAA2; TP53I4; SAA1
Positive Sample:
Mouse liver,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Secreted.
Calculated MW:
12kDa
Observed MW:
16kDa
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
6288
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SAA1 Rabbit pAb (CAB14553) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
