The S1PR1 Polyclonal Antibody (CAB12935) is a valuable tool for researchers studying the sphingosine-1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor involved in cell migration and immune response regulation. This antibody, produced in rabbits, exhibits high specificity for human samples and is suitable for Western blot applications. By targeting the S1PR1 protein, researchers can effectively detect and analyze its expression in various cell types, making it well-suited for studies in immunology, cancer biology, and drug development.
S1PR1 plays a crucial role in immune cell trafficking, vascular integrity, and lymphocyte egress from lymphoid organs. Dysregulation of S1PR1 signaling has been linked to inflammatory diseases, autoimmune disorders, and cancer progression, highlighting its potential as a therapeutic target. By gaining insights into the function of S1PR1, researchers can advance the development of novel treatments for a range of diseases where immune cell mobilization and trafficking are key factors.
Product Name:
EDG1/HEXIM1 Rabbit Polyclonal Antibody
SKU:
CAB12935
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 303-382 of human EDG1/HEXIM1 (NP_001391.2).
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1901
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EDG1/HEXIM1 antibody (CAB12935) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
