The S100A13 Monoclonal Antibody (PAC020381) is a valuable tool for researchers studying S100A13, a calcium-binding protein involved in various cellular processes such as cell proliferation, differentiation, and migration. This antibody, produced through Paco antibodies, is highly specific to human S100A13 and is validated for use in immunohistochemistry and Western blot applications.S100A13 is known to interact with various proteins and play a role in tumor growth and metastasis, making it a potential target for cancer research. Its involvement in angiogenesis and cell signaling pathways also makes it a promising candidate for studies in cardiovascular and neurological diseases.
The S100A13 Monoclonal Antibody enables precise detection and analysis of S100A13 expression in different cell types, allowing researchers to investigate its role in disease development and progression.Overall, the S100A13 Monoclonal Antibody offers researchers a reliable tool for studying the functions and mechanisms of S100A13 in various physiological and pathological conditions, paving the way for potential therapeutic targets and interventions in cancer and other diseases.
Antibody Name:
S100A13 Antibody (PACO20381)
Antibody SKU:
PACO20381
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human S100A13
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20381(S100A13 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20381(S100A13 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland.
Synonyms:
S100 calcium binding protein A13
UniProt Protein Function:
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
NCBI Summary:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
