The S100A13 Antibody (PAC020380) is a highly specific tool for researchers studying the S100A13 protein, which is involved in various cellular processes including cell signaling, proliferation, and differentiation. This polyclonal antibody, raised in rabbits, exhibits strong reactivity towards human samples and has been validated for use in Western blot applications. By binding to the S100A13 protein, this antibody enables the detection and analysis of S100A13 expression in different cell types, making it a valuable asset for studies in molecular biology, cancer research, and developmental biology.
S100A13 is a member of the S100 family of calcium-binding proteins and is known to play a role in tumor progression, angiogenesis, and metastasis in various cancers. Its involvement in these critical processes makes it a promising target for therapeutic interventions aimed at combating cancer progression and improving patient outcomes. Understanding the function and regulation of S100A13 is essential for advancing our knowledge of cancer biology and identifying novel treatment strategies targeting this protein.
Antibody Name:
S100A13 Antibody (PACO20380)
Antibody SKU:
PACO20380
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human S100A13
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20380(S100A13 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 2 minutes.
Background:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland.
Synonyms:
S100 calcium binding protein A13
UniProt Protein Function:
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
NCBI Summary:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
