The RXRalpha Rabbit Monoclonal Antibody (CAB19105) is a valuable tool for researchers studying the retinoid X receptor alpha (RXRalpha), a nuclear receptor involved in regulating gene expression and various biological processes. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting RXRalpha protein levels in human samples, making it suitable for use in Western blot and immunohistochemistry applications.RXRalpha is a key player in mediating the effects of retinoids, which are essential for cell growth, differentiation, and apoptosis.
Dysregulation of RXRalpha signaling has been linked to various diseases, including cancer, metabolic disorders, and neurodegenerative conditions. By targeting RXRalpha with this monoclonal antibody, researchers can gain insights into its role in disease pathogenesis and potential therapeutic strategies.Overall, the RXRalpha Rabbit Monoclonal Antibody (CAB19105) offers researchers a reliable tool for exploring the functions and molecular mechanisms of RXRalpha, paving the way for advancements in drug discovery and personalized medicine.
Product Name:
RXRα Rabbit Monoclonal Antibody
SKU:
CAB19105
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RXRα (P19793).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsChIP,5μg antibody for 10μg-15μg of ChromatinChIP-seq,1:50 - 1:100
Synonyms:
NR2B1; RXRalpha; RXR-alpha; RXRα
Positive Sample:
MCF7, HepG2, BxPC-3, Mouse lung, Rat lung, Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Nucleus, Cytoplasm, Mitochondrion
Calculated MW:
51kDa
Observed MW:
60kDa
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6256
Clone Number:
ARC0468
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Chromatin immunoprecipitation was performed with 25 μg of cross-linked chromatin from HepG2 cells using 5 μg of RXRα Rabbit mAb (CAB19105). DNA libraries were prepared using Scale ssDNA-seq Lib Prep Kit for Illumina V2 (RK20228). The ChIP sequencing results indicate the enrichment pattern of RXRα across chromosome 19 (upper panel) and the genomic region encompassing ECH1, a representative gene enriched in RXRα (lower panel).
