The RuvC Antibody (PAC034922) is a highly specific and sensitive tool for researchers studying DNA repair and recombination processes. This polyclonal antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunofluorescence. It specifically targets the RuvC protein, a key player in DNA repair mechanisms, allowing for precise detection and analysis in a variety of cell types.The RuvC protein is essential for resolving Holliday junctions during DNA recombination, making it a crucial component in maintaining genome stability. Dysregulation of RuvC activity can lead to genomic instability and predispose cells to mutations and cancer development.
By studying the function of RuvC, researchers can gain valuable insights into the mechanisms of DNA repair and potentially identify new therapeutic targets for cancer treatment and prevention.Overall, the RuvC Antibody (PAC034922) is a valuable tool for researchers interested in unraveling the intricacies of DNA repair pathways and their implications for human health and disease. Its high specificity and sensitivity make it an ideal choice for studies investigating the role of RuvC in genome maintenance and cellular homeostasis.
Antibody Name:
ruvC Antibody (PACO34922)
Antibody SKU:
PACO34922
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Crossover junction endodeoxyribonuclease RuvC protein (2-173AA)
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
UniProt Protein Details:
NCBI Summary:
RuvABC is an enzymatic complex which functions in recombination pathways to by binding to recombinational junctions and catalyzing strand cleavage and branch migration. [More information is available at EcoCyc: EG10925].
