The RUVBL2 Polyclonal Antibody (CAB12564) is a valuable tool for researchers studying the RUVBL2 protein, a critical component of various cellular processes including DNA damage repair, chromatin remodeling, and cell cycle regulation. This antibody, generated in rabbits, demonstrates high specificity and sensitivity towards human samples, making it suitable for Western blot applications.RUVBL2, also known as pontin or reptin, is a member of the AAA+ ATPase family and is known to interact with a wide range of proteins involved in transcriptional regulation, DNA repair, and chromatin remodeling. Its diverse functions make it a key player in cellular homeostasis and its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders.
By using the RUVBL2 Polyclonal Antibody (CAB12564), researchers can investigate the expression levels and localization of RUVBL2 in different cell types and conditions, providing valuable insights into its role in cellular processes and disease pathology. This antibody is a reliable tool for furthering our understanding of RUVBL2 biology and may pave the way for the development of novel therapeutic strategies targeting this protein.
Product Name:
Reptin/RUVBL2 Rabbit Polyclonal Antibody
SKU:
CAB12564
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-463 of human Reptin/Reptin/RUVBL2 (NP_006657.1).
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
Purification Method:
Affinity purification
Gene ID:
10856
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Reptin/Reptin/RUVBL2 antibody (CAB12564) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
