The RUVBL1 Polyclonal Antibody (CAB14195) is a valuable tool for researchers studying the RUVBL1 protein, which plays a critical role in cellular processes such as DNA repair, transcriptional regulation, and chromatin remodeling. This antibody, developed using rabbits as the host, is highly specific for human samples and is validated for use in Western blot applications.RUVBL1, a member of the AAA+ superfamily of ATPases, is involved in various cellular pathways essential for maintaining genomic integrity and regulating gene expression. Its function in DNA repair mechanisms and transcriptional regulation makes it a promising target for research into cancer, aging, and other disorders related to genomic instability.
By specifically binding to the RUVBL1 protein, this polyclonal antibody enables accurate detection and analysis of RUVBL1 expression levels in different cell types and experimental conditions. Its high reactivity and reliability make it an ideal tool for investigating the biological functions and mechanisms of RUVBL1 in the context of various diseases and physiological processes.
Product Name:
RUVBL1/TIP49A/PONTIN Rabbit Polyclonal Antibody
SKU:
CAB14195
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-214 of human RUVBL1/TIP49A/PONTIN (NP_003698.1).
This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8607
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RUVBL1/TIP49A/PONTIN antibody (CAB14195) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
