The RUVA Antibody (PACO34778) is a highly specific polyclonal antibody designed for research involving the RUVA protein, which plays a key role in DNA repair mechanisms. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunofluorescence.RUVA is a crucial protein involved in the resolution of Holliday junctions during homologous recombination, ensuring the fidelity of DNA repair processes. The RUVA Antibody enables the detection and analysis of RUVA protein expression in different cell types, making it ideal for studies in genetics, molecular biology, and cancer research.
Understanding the function and regulation of RUVA is essential for unraveling the mechanisms underlying DNA repair and genetic stability. Research on RUVA could lead to insights into genetic diseases, cancer development, and potential therapeutic targets for improving DNA repair processes. Explore the potential of the RUVA Antibody in your research to advance knowledge in the field of molecular biology and genetics.
Antibody Name:
ruvA Antibody (PACO34778)
Antibody SKU:
PACO34778
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Holliday junction ATP-dependent DNA helicase RuvA protein (1-203AA)
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA.
Synonyms:
Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12), ruvA
UniProt Protein Function:
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA.
UniProt Protein Details:
NCBI Summary:
Binds Holliday junction as two tetramers (an octamer) and each tetrameric half recruits one RuvB hexameric helicase. [More information is available at EcoGene: EG10923]. RuvABC is an enzymatic complex which functions in recombination pathways to by binding to recombinational junctions and catalyzing strand cleavage and branch migration. [More information is available at EcoCyc: RUVA].
