UniProt Protein Function: | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA. |
UniProt Protein Details: | |
NCBI Summary: | Binds Holliday junction as two tetramers (an octamer) and each tetrameric half recruits one RuvB hexameric helicase. [More information is available at EcoGene: EG10923]. RuvABC is an enzymatic complex which functions in recombination pathways to by binding to recombinational junctions and catalyzing strand cleavage and branch migration. [More information is available at EcoCyc: RUVA]. |
UniProt Code: | P0A809 |
NCBI GenInfo Identifier: | 16129814 |
NCBI Gene ID: | 946369 |
NCBI Accession: | NP_416375.1 |
UniProt Secondary Accession: | P0A809,P08576 |
UniProt Related Accession: | P0A809 |
Molecular Weight: | 22,086 Da |
NCBI Full Name: | component of RuvABC resolvasome, regulatory subunit |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | ruvAÂ Â |
NCBI Official Synonym Symbols: | ECK1862; JW1850Â Â |
NCBI Protein Information: | component of RuvABC resolvasome, regulatory subunit |
UniProt Protein Name: | Holliday junction ATP-dependent DNA helicase RuvA |
UniProt Synonym Protein Names: | |
Protein Family: | Holliday junction ATP-dependent DNA helicase |
UniProt Gene Name: | ruvAÂ Â |
UniProt Entry Name: | RUVA_ECOLI |