RUNX2 Rabbit Polyclonal Antibody (CAB2851)
- SKU:
- CAB2851
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Product Name: | RUNX2 Rabbit Polyclonal Antibody |
SKU: | CAB2851 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 242-521 of human RUNX2 (NP_001019801.3). |
Sequence: | FSDR LSDL GRIP HPSM RVGV PPQN PRPS LNSA PSPF NPQG QSQI TDPR QAQS SPPW SYDQ SYPS YLSQ MTSP SIHS TTPL SSTR GTGL PAIT DVPR RISD DDTA TSDF CLWP STLS KKSQ AGAS ELGP FSDP RQFP SISS LTES RFSN PRMH YPAT FTYT PPVT SGMS LGMS ATTH YHTY LPPP YPGS SQSQ SGPF QTSS TPYL YYGT SSGS YQFP MVPG GDRS PSRM LPPC TTTS NGST LLNP NLPN QNDG VDAD GSHS SSPT VLNS SGRM DESV WRPY |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; RUNX2 |
Positive Sample: | MCF7,HeLa,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 57kDa |
Observed MW: | 60kDa |
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Purification Method: | Affinity purification |
Gene ID: | 860 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |