RUNX2 Rabbit Monoclonal Antibody (CAB11753)
- SKU:
- CAB11753
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AML3
- CBF-alpha-1
- CBFA1
- CCD
- CCD1
- CLCD
- OSF-2
- OSF2
- PEA2aA
- PEBP2aA
Description
Product Name: | RUNX2 Rabbit Monoclonal Antibody |
SKU: | CAB11753 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 336-439 of human RUNX2 (Q13950). |
Sequence: | PRRI SDDD TATS DFCL WPST LSKK SQAG ASEL GPFS DPRQ FPSI SSLT ESRF SNPR MHYP ATFT YTPP VTSG MSLG MSAT THYH TYLP PPYP GSSQ SQSG PFQT |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; RUNX2 |
Positive Sample: | U2OS,PC-3,U-937,Mouse testis,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleoplasm, nucleus |
Calculated MW: | 57kDa |
Observed MW: | 60kDa |
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Purification Method: | Affinity purification |
Gene ID: | 860 |
Clone Number: | ARC0362 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |