The Anti-Runx2 Antibody (CAB11753) is a valuable tool for researchers studying the Runx2 protein, a key regulator of osteoblast differentiation and bone formation. This antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunohistochemistry. By specifically binding to the Runx2 protein, this antibody enables accurate detection and analysis in a wide range of cell types and tissues.Runx2, a transcription factor essential for bone development, has also been implicated in various diseases, including osteoporosis and certain types of cancer.
By studying the expression and activity of Runx2, researchers can gain valuable insights into bone biology and potential therapeutic targets for bone-related disorders. The Anti-Runx2 Antibody provides a reliable tool for investigating the role of Runx2 in both normal physiological processes and pathological conditions.
Product Name:
RUNX2 Rabbit Monoclonal Antibody
SKU:
CAB11753
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 336-439 of human RUNX2 (Q13950).
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Purification Method:
Affinity purification
Gene ID:
860
Clone Number:
ARC0362
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RUNX2 Rabbit mAb (CAB11753) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
