Rubicon Rabbit Polyclonal Antibody (CAB13169)
- SKU:
- CAB13169
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
Product Name: | Rubicon Rabbit Polyclonal Antibody |
SKU: | CAB13169 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Rubicon (NP_055502.1). |
Sequence: | MRPE GAGM ELGG GEER LPEE SRRE HWQL LGNL KTTV EGLV STNS PNVW SKYG GLER LCRD MQSI LYHG LIRD QACR RQTD YWQF VKDI RWLS PHSA LHVE KFIS VHEN DQSS ADGA SERA VAEL WLQH SLQY HCLS AQLR PLLG DRQY IRKF YTDA AFLL SDAH VTAM LQCL EAVE QNNP RLLA QIDA SMFA RKHE SPLL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SCAR15; RUBICON; KIAA0226; Rubicon |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Early endosome, Late endosome, Lysosome. |
Calculated MW: | 109kDa |
Observed MW: | 108kDa |
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9711 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |