The RTN4R Polyclonal Antibody (CAB5847) is a valuable tool for researchers studying RTN4R, a cell surface receptor involved in neural regeneration and plasticity. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to the RTN4R protein, this antibody allows for the detection and analysis of RTN4R expression in various cell types, making it ideal for studies in neuroscience and neurodegenerative diseases.
RTN4R, also known as Nogo receptor, is a key regulator of axonal growth and regeneration in the central nervous system. Its role in inhibiting nerve regeneration makes it a potential target for therapeutic interventions in spinal cord injury, stroke, and neurodegenerative disorders such as multiple sclerosis. Understanding the function of RTN4R at the molecular level is essential for developing strategies to promote neural regeneration and recovery in these clinical contexts.
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Purification Method:
Affinity purification
Gene ID:
65078
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NOGO Receptor 1 (RTN4R) antibody (CAB5847) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
