The RTN4IP1 Polyclonal Antibody (PAC039510) is a valuable tool for researchers studying the RTN4IP1 protein, which is involved in various cellular processes including apoptosis, cell cycle regulation, and cellular stress response. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the RTN4IP1 protein, researchers can effectively detect and analyze its expression in different cell types, making it a versatile tool for studies in cell biology and cancer research.
RTN4IP1, also known as NOGO-interacting protein, is a key player in regulating cell survival and death mechanisms, making it a potential target for therapies aimed at manipulating cellular responses to stress and disease. Understanding the function of RTN4IP1 can provide important insights into potential therapeutic targets for conditions such as cancer, neurodegenerative disorders, and cardiovascular diseases. Research into RTN4IP1 may lead to the development of novel treatment strategies that capitalize on its role in cellular signaling pathways.
Antibody Name:
RTN4IP1 Antibody (PACO39510)
Antibody SKU:
PACO39510
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Reticulon-4-interacting protein 1, mitochondrial protein (41-396AA)
Immunohistochemistry of paraffin-embedded human appendix tissue using PACO39510 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39510 at dilution of 1:100.
Background:
Appears to be a potent inhibitor of regeneration following spinal cord injury.
Synonyms:
Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein), RTN4IP1, NIMP
UniProt Protein Function:
RTN4IP1: Appears to be a potent inhibitor of regeneration following spinal cord injury. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 6q21
UniProt Protein Details:
NCBI Summary:
This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
