The RTN4 Polyclonal Antibody (CAB1752) is designed for research involving RTN4, a protein involved in axonal regeneration and neural growth. This antibody, produced in rabbits, is highly reactive with human and mouse samples, and has been validated for use in various applications including Western blot, immunohistochemistry, and immunofluorescence.RTN4, also known as Nogo-A, is a key player in the inhibition of axonal growth and regeneration in the central nervous system. By targeting RTN4 with this specific antibody, researchers can study its role in neural development and potential therapeutic strategies for conditions such as spinal cord injuries, stroke, and neurodegenerative diseases.
The importance of RTN4 in neural regeneration and growth makes this polyclonal antibody a valuable tool for studies in neuroscience and neurology. Its high reactivity and reliability in various applications make it a versatile option for researchers looking to understand the molecular mechanisms underlying neural plasticity and repair.
Product Name:
RTN4 Rabbit Polyclonal Antibody
SKU:
CAB1752
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human RTN4 (NP_065393.1).
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
57142
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using RTN4 Rabbit pAb (CAB1752) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
