RTN3 Rabbit Polyclonal Antibody (CAB15129)
- SKU:
- CAB15129
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | RTN3 Rabbit Polyclonal Antibody |
SKU: | CAB15129 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1). |
Sequence: | YKSV IQAV QKSE EGHP FKAY LDVD ITLS SEAF HNYM NAAM VHIN RALK LIIR LFLV EDLV DSLK LAVF MWLM TYVG AVFN GITL LILA ELLI FSVP IVYE KYKT QIDH YVGI ARDQ TKSI VEKI QAKL PGIA KKKA E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HAP; ASYIP; NSPL2; NSPLII; RTN3-A1; RTN3 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein. |
Calculated MW: | 113kDa |
Observed MW: | 26kDa |
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
Purification Method: | Affinity purification |
Gene ID: | 10313 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |