The RTKN2 Polyclonal Antibody (PAC037682) is a valuable tool for researchers studying the Rhotekin 2 (RTKN2) protein, which plays a crucial role in various cellular processes, including cell migration and adhesion. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.RTKN2 is known to interact with Rho GTPases, contributing to the regulation of actin cytoskeleton dynamics and cell motility. Dysregulation of RTKN2 expression has been linked to cancer progression and metastasis, making it a promising target for cancer research.
By enabling the detection and analysis of RTKN2 in different cell types, this antibody is ideal for investigating the functions of RTKN2 in cellular pathways and its potential implications in cancer biology. Understanding the role of RTKN2 can provide insights into the mechanisms underlying tumor development and metastasis, leading to the development of novel therapeutic strategies targeting RTKN2 signaling pathways.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO37682 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO37682 at dilution of 1:100.
Background:
May play an important role in lymphopoiesis.
Synonyms:
Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1), RTKN2, PLEKHK1
UniProt Protein Function:
RTKN2: a Rho-GTPase effector protein with a PH domain. Expressed in CD4+ T-cells and bone marrow-derived B-cells. Gene expression was increased in quiescent T-cells and negligible in activated proliferating cells. Expression was absent in myeloid leukaemias, low in most B-cell malignancies and CD8+ T-cell malignancies, but very high in double positive T-lymphoblastic lymphoma. Three alternatively spliced variants have been reported in human samples.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q21.2Cellular Component: plasma membraneBiological Process: positive regulation of cell proliferation; hemopoiesis; signal transduction
rhotekin-2; PH domain-containing family K member 1; pleckstrin homology domain-containing family K member 1; pleckstrin homology domain containing, family K member 1
UniProt Protein Name:
Rhotekin-2
UniProt Synonym Protein Names:
Pleckstrin homology domain-containing family K member 1; PH domain-containing family K member 1
