The RTKN2 Polyclonal Antibody (PAC011978) is a valuable tool for research involving the RTKN2 protein, which plays a role in various cellular processes, including cell adhesion, migration, and signaling. This antibody, developed using rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the RTKN2 protein, researchers can easily detect and analyze its expression in different cell types, making it ideal for studies in cell biology and cancer research.
RTKN2, also known as Rhotekin 2, is a key player in cell adhesion and migration, contributing to processes such as tissue development and wound healing. Its involvement in signaling pathways linked to cell growth and survival makes it a promising target for studying diseases like cancer and neurological disorders. By investigating the function of RTKN2, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic strategies.
RTKN2: a Rho-GTPase effector protein with a PH domain. Expressed in CD4+ T-cells and bone marrow-derived B-cells. Gene expression was increased in quiescent T-cells and negligible in activated proliferating cells. Expression was absent in myeloid leukaemias, low in most B-cell malignancies and CD8+ T-cell malignancies, but very high in double positive T-lymphoblastic lymphoma. Three alternatively spliced variants have been reported in human samples.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q21.2Cellular Component: plasma membraneBiological Process: positive regulation of cell proliferation; hemopoiesis; signal transduction
rhotekin-2; PH domain-containing family K member 1; pleckstrin homology domain-containing family K member 1; pleckstrin homology domain containing, family K member 1
UniProt Protein Name:
Rhotekin-2
UniProt Synonym Protein Names:
Pleckstrin homology domain-containing family K member 1; PH domain-containing family K member 1
