RTKN Rabbit Polyclonal Antibody (CAB13349)
- SKU:
- CAB13349
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | RTKN Rabbit Polyclonal Antibody |
SKU: | CAB13349 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human RTKN (NP_001015056.1). |
Sequence: | PLCM TQPT ASGT LRVQ QAGE MQNW AQVH GVLK GTNL FCYR QPED ADTG EEPL LTIA VNKE TRVR AGEL DQAL GRPF TLSI SNQY GDDE VTHT LQTE SREA LQSW MEAL WQLF FDMS QWKQ CCDE IMKI ETPA PRKP PQAL AKQG SLYH EMAI EPLD DIAA VTDI LTQR EGAR LETP PPWL AMFT DQPA LPNP CSPA SVAP APDW THPL PWGR PRTF SLDA VPPD HSPR ARSV APLP PQRS PRTR GLCS KGQP RTWL QSPV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | RTKN; rhotekin |
Positive Sample: | A-431,MCF7,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 63kDa |
Observed MW: | 63kDa |
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 6242 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |