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RTEL1 Antibody (PACO46182)

SKU:
PACO46182
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • RTEL1 Antibody PACO46182
  • RTEL1 Antibody PACO46182
  • RTEL1 Antibody PACO46182
€359

Description

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RTEL1 Antibody (PACO46182)

The RTEL1 Polyclonal Antibody (PAC046182) is a valuable tool for researchers studying the RTEL1 protein, which plays a key role in telomere maintenance and DNA replication. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.RTEL1 is essential for the stability and integrity of telomeres, the protective caps at the ends of chromosomes that are crucial for maintaining genomic stability. Dysregulation of telomere maintenance can lead to genomic instability, aging, and various human diseases, including cancer.

By targeting the RTEL1 protein, researchers can gain insight into the molecular mechanisms underlying these processes and potentially identify new therapeutic targets for cancer and other telomere-related disorders.With its specificity and sensitivity in detecting RTEL1 in various cell types, the PAC046182 antibody is an excellent tool for immunology and cancer research. By using this antibody, researchers can further explore the functions and regulatory pathways of RTEL1, ultimately advancing our understanding of telomere biology and its impact on human health.

Antibody Name:RTEL1 Antibody (PACO46182)
Antibody SKU:PACO46182
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Regulator of telomere elongation helicase 1 protein (975-1219AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human small intestine tissue using PACO46182 at dilution of 1:100.
Product ImageImmunofluorescent analysis of HepG2 cells using PACO46182 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human testis tissue using PACO46182 at dilution of 1:100.
Background:ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
Synonyms:Regulator of telomere elongation helicase 1 (EC 3.6.4.12) (Novel helicase-like), RTEL1, C20orf41 KIAA1088 NHL
UniProt Protein Function:RTEL1: ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function. Belongs to the helicase family. RAD3/XPD subfamily. 8 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.12; DNA repair, damage; HelicaseChromosomal Location of Human Ortholog: 20q13.3Cellular Component: nucleusMolecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP bindingBiological Process: DNA repair; telomere maintenance; DNA duplex unwindingDisease: Dyskeratosis Congenita, Autosomal Recessive, 5; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 3
UniProt Protein Details:
NCBI Summary:This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
UniProt Code:Q9NZ71
NCBI GenInfo Identifier:545688900
NCBI Gene ID:51750
NCBI Accession:NP_001269938.1
UniProt Secondary Accession:Q9NZ71,Q5JTV3, Q5JTV4, Q9BW37, Q9H402, A2A397, A2A398 B4DRM5, B4DYM3, B4E3N6
UniProt Related Accession:Q9NZ71
Molecular Weight:133,683 Da
NCBI Full Name:regulator of telomere elongation helicase 1 isoform 3
NCBI Synonym Full Names:regulator of telomere elongation helicase 1
NCBI Official Symbol:RTEL1  
NCBI Official Synonym Symbols:NHL; RTEL; DKCA4; DKCB5; C20orf41  
NCBI Protein Information:regulator of telomere elongation helicase 1; regulator of telomere length
UniProt Protein Name:Regulator of telomere elongation helicase 1
UniProt Synonym Protein Names:Novel helicase-like
Protein Family:Regulator of telomere elongation helicase
UniProt Gene Name:RTEL1  
UniProt Entry Name:RTEL1_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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