The RTCB Polyclonal Antibody (PACO34526) is a valuable tool for researchers studying RTCB, a key protein involved in RNA processing and DNA repair. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting RTCB in human samples, making it an ideal choice for Western blot applications. By targeting the RTCB protein, this antibody allows for accurate analysis and quantification of RTCB levels in various cell types, providing valuable insights into RNA metabolism and genome stability.RTCB is known for its role in maintaining genomic integrity and ensuring proper gene expression, making it a crucial player in cellular processes such as DNA replication and transcription.
Dysregulation of RTCB has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting the importance of understanding its function and regulation. By utilizing the RTCB Polyclonal Antibody, researchers can further investigate the role of RTCB in disease development and potentially identify novel therapeutic targets for these conditions.
Antibody Name:
rtcB Antibody (PACO34526)
Antibody SKU:
PACO34526
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli RNA-splicing ligase RtcB protein (1-408AA)
RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester.
Synonyms:
RNA-splicing ligase RtcB (EC 6.5.1.-), rtcB, yhgL
UniProt Protein Function:
RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP (PubMed:21224389, PubMed:22730297). Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases (PubMed:24218597).
UniProt Protein Details:
NCBI Summary:
RtcB has similarity to proteins found in Eucarya, Bacteria, and Archaea . [More information is available at EcoCyc: G7751].
