The RTCA Polyclonal Antibody (PACO6025) is a valuable tool for researchers studying the RTCA protein, a key regulator of cellular processes. This antibody, produced through rabbit immunization, has high specificity for human samples and is validated for use in Western blot applications. By binding to the RTCA protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in cell biology and drug development.
RTCA, also known as a critical signaling molecule, plays a crucial role in regulating cellular functions such as proliferation, differentiation, and apoptosis. Its involvement in various biological processes makes it a promising target for research on cancer, neurodegenerative diseases, and metabolic disorders. Understanding the functions of RTCA is essential for developing novel therapeutic strategies that target this protein for disease intervention and treatment.
Antibody Name:
RTCA Antibody (PACO06025)
Antibody SKU:
PACO06025
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human RTCD1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
RTCD1: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; EC 6.5.1.4; RNA-bindingChromosomal Location of Human Ortholog: 1p21.2Cellular Component: nucleoplasm; nucleusMolecular Function: RNA binding; RNA-3'-phosphate cyclase activity; ATP bindingBiological Process: RNA processing
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
