UniProt Protein Function: | R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Cell development/differentiation; SecretedChromosomal Location of Human Ortholog: 8q23.1Cellular Component: extracellular space; cell surface; extracellular regionMolecular Function: heparin binding; G-protein-coupled receptor binding; receptor bindingBiological Process: embryonic forelimb morphogenesis; osteoblast differentiation; Wnt receptor signaling pathway; embryonic hindlimb morphogenesis; bone mineralization |
UniProt Protein Details: | |
NCBI Summary: | R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6UXX9 |
NCBI GenInfo Identifier: | 222446611 |
NCBI Gene ID: | 340419 |
NCBI Accession: | NP_848660.3 |
UniProt Secondary Accession: | Q6UXX9,Q4G0U4, Q8N6X6, B3KVP0 |
UniProt Related Accession: | Q6UXX9 |
Molecular Weight: | 22.0kD |
NCBI Full Name: | R-spondin-2 isoform 1 |
NCBI Synonym Full Names: | R-spondin 2 |
NCBI Official Symbol: | RSPO2Â Â |
NCBI Official Synonym Symbols: | CRISTIN2Â Â |
NCBI Protein Information: | R-spondin-2; R-spondin 2 homolog; roof plate-specific spondin-2 |
UniProt Protein Name: | R-spondin-2 |
UniProt Synonym Protein Names: | Roof plate-specific spondin-2 |
Protein Family: | R-spondin |
UniProt Gene Name: | RSPO2Â Â |
UniProt Entry Name: | RSPO2_HUMAN |