The RSPO2 Polyclonal Antibody (PAC011975) is specially developed for research involving RSPO2, a crucial signaling protein in the Wnt signaling pathway that plays a key role in stem cell regulation and development. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent tool for various experimental applications such as Western blotting.RSPO2 is known for its involvement in numerous cellular processes, including cell proliferation, differentiation, and tissue regeneration. Its dysregulation has been linked to various diseases, such as cancer and developmental disorders, highlighting the importance of studying its function.
By utilizing the RSPO2 Polyclonal Antibody, researchers can detect and analyze RSPO2 expression in different cell types, facilitating research in developmental biology, cancer biology, and regenerative medicine.Furthermore, understanding the role of RSPO2 in signaling pathways can provide insights into potential therapeutic targets for diseases associated with abnormal cell growth and differentiation. The RSPO2 Polyclonal Antibody is a valuable tool for scientists seeking to unravel the complexities of RSPO2-mediated signaling and its implications in health and disease.
R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Cell development/differentiation; SecretedChromosomal Location of Human Ortholog: 8q23.1Cellular Component: extracellular space; cell surface; extracellular regionMolecular Function: heparin binding; G-protein-coupled receptor binding; receptor bindingBiological Process: embryonic forelimb morphogenesis; osteoblast differentiation; Wnt receptor signaling pathway; embryonic hindlimb morphogenesis; bone mineralization
UniProt Protein Details:
NCBI Summary:
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
