The RRM1 Polyclonal Antibody (CAB1152) is a versatile tool for researchers studying the RRM1 protein, which plays a crucial role in DNA replication and repair processes. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the RRM1 protein, this antibody allows for the detection and analysis of RRM1 in various cell types, making it ideal for research in the fields of molecular biology and cancer biology.RRM1 is a key component of the ribonucleotide reductase complex, which is responsible for converting ribonucleotides to deoxyribonucleotides, essential for DNA synthesis and repair.
Dysregulation of RRM1 has been implicated in cancer development and progression, making it a promising target for therapeutic interventions. By studying the function and expression of RRM1, researchers can gain valuable insights into tumor biology and potential treatment strategies.The RRM1 Polyclonal Antibody (CAB1152) is a valuable tool for investigating the role of RRM1 in cancer biology and DNA replication processes. Its high specificity and sensitivity make it an ideal choice for researchers looking to advance our understanding of RRM1 and its implications in disease development.
Product Name:
RRM1 Rabbit Polyclonal Antibody
SKU:
CAB1152
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 593-792 of human RRM1 (NP_001024.1).
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
R1; RR1; RIR1; RRM1
Positive Sample:
HeLa,A-549,Raji,Mouse testis,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm.
Calculated MW:
90kDa
Observed MW:
90kDa
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RRM1 Rabbit pAb (CAB1152) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
