The RRAGB Polyclonal Antibody (PAC011965) is a valuable tool for researchers studying RRAGB, a member of the Ras-related GTP-binding protein family involved in the regulation of mTOR complex 1 (mTORC1) signaling pathway. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. By specifically binding to the RRAGB protein, this antibody enables the accurate detection and analysis of RRAGB expression in various cell types.RRAGB plays a crucial role in the activation of mTORC1, a signaling pathway that regulates cell growth, metabolism, and autophagy. Dysregulation of the mTORC1 pathway has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
By studying RRAGB expression and function, researchers can gain insight into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.In summary, the RRAGB Polyclonal Antibody is a reliable research tool that can enhance studies in cell biology, cancer research, and metabolic disorders by enabling the precise detection and analysis of RRAGB protein expression. Its high reactivity and specificity make it an essential component for understanding the role of RRAGB in mTORC1 signaling and its implications for human health.
RRAGB: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xp11.21Cellular Component: cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleusMolecular Function: GTP binding; GTPase activity; guanyl ribonucleotide binding; protein bindingBiological Process: cell cycle arrest; cellular response to amino acid starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of TOR signaling pathway
UniProt Protein Details:
NCBI Summary:
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
