RRAGA/RRAGB Antibody (PACO06793)
- SKU:
- PACO06793
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RRAGA/RRAGB Antibody (PACO06793)
The RRAGA/RRAGB Polyclonal Antibody (PACO06793) is a vital tool for researchers studying the Rag GTPases, key regulators of the mTOR pathway and cellular growth. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for Western blot applications. By targeting the RRAGA and RRAGB proteins, this antibody enables precise detection and analysis in various cell types, facilitating investigations in the fields of cell biology and cancer research.The Rag GTPases, consisting of RRAGA and RRAGB, play a crucial role in sensing nutrient availability and regulating cell growth through the mTOR signaling pathway.
Dysregulation of this pathway is implicated in various diseases, including cancer, making the RRAGA/RRAGB antibody an invaluable tool for understanding the mechanisms underlying these conditions. By studying the activity of RRAGA and RRAGB, researchers can gain insights that may lead to the development of targeted therapies for cancer and other mTOR-related disorders.
| Antibody Name: | RRAGA/RRAGB Antibody (PACO06793) |
| Antibody SKU: | PACO06793 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human Rag A/B. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of Jurkat NIH-3T3 cells using Rag A/B Polyclonal Antibody. |
 | Western Blot analysis of HepG2 cells using Rag A/B Polyclonal Antibody. |
| Synonyms: | RRAGA; Ras-related GTP-binding protein A; Rag A; RagA; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1; RRAGB; Ras-related GTP-binding protein B; Rag B; RagB |
| UniProt Protein Function: | RRAGA: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF- alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Belongs to the GTR/RAG GTP-binding protein family. |
| UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 9p22.1 Cellular Component: cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleus Molecular Function:GTP binding; GTPase activity; phosphoprotein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; ubiquitin protein ligase binding Biological Process: apoptosis; cell cycle arrest; cell death; cellular response to amino acid starvation; gene expression; insulin receptor signaling pathway; macroautophagy; negative regulation of autophagy; positive regulation of cytolysis; positive regulation of TOR signaling pathway; transcription initiation from RNA polymerase II promoter; virus-host interaction |
| UniProt Code: | Q7L523 |
| NCBI GenInfo Identifier: | 74759007 |
| NCBI Gene ID: | 10670 |
| NCBI Accession: | Q7L523.1 |
| UniProt Secondary Accession: | Q7L523,O00290, Q15347, B2R7L1, |
| UniProt Related Accession: | Q7L523 |
| Molecular Weight: | 36,566 Da |
| NCBI Full Name: | Ras-related GTP-binding protein A |
| NCBI Synonym Full Names: | Ras related GTP binding A |
| NCBI Official Symbol: | RRAGAÂ Â |
| NCBI Official Synonym Symbols: | FIP1; RAGA; FIP-1Â Â |
| NCBI Protein Information: | ras-related GTP-binding protein A |
| UniProt Protein Name: | Ras-related GTP-binding protein A |
| UniProt Synonym Protein Names: | Adenovirus E3 14.7 kDa-interacting protein 1 |
| UniProt Gene Name: | RRAGAÂ Â |
| UniProt Entry Name: | RRAGA_HUMAN |
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