The RRAD Polyclonal Antibody (PACO01393) is a valuable tool for researchers studying RRAD, a protein involved in insulin signaling and glucose metabolism. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting RRAD in human samples, making it an ideal choice for Western blot applications. By binding to the RRAD protein, this antibody facilitates the analysis of RRAD expression levels in various cell types, aiding in investigations related to metabolism, diabetes, and other related diseases.RRAD, a member of the Ras-related GTPase family, plays a crucial role in regulating insulin sensitivity and glucose uptake in cells.
Dysregulation of RRAD expression has been implicated in insulin resistance, type 2 diabetes, and metabolic disorders. Therefore, studying RRAD and its functions is essential for gaining insights into the molecular mechanisms underlying these conditions and potentially identifying new therapeutic targets.In conclusion, the RRAD Polyclonal Antibody is a valuable tool for researchers interested in unraveling the role of RRAD in metabolic processes and its implications for human health. Its specificity, sensitivity, and reliability make it a reliable choice for studies in the fields of metabolism, diabetes, and related disorders.
Antibody Name:
RRAD Antibody
Antibody SKU:
PACO01393
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Rad GTPase.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RRAD; RAD; GTP-binding protein RAD; RAD1; Ras associated with diabetes
UniProt Protein Function:
RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
