The RPP40 Polyclonal Antibody (CAB17086) is a valuable tool for researchers studying RPP40, a key protein involved in ribonucleoprotein complex assembly and RNA processing. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and immunohistochemistry applications.RPP40 is essential for the proper functioning of the spliceosome, a complex molecular machine responsible for removing introns from pre-mRNA molecules. Dysregulation of RPP40 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular homeostasis.
By targeting RPP40 with this polyclonal antibody, researchers can gain valuable insights into its expression levels, subcellular localization, and interactions with other proteins. This information is crucial for elucidating the molecular mechanisms underlying RNA processing and spliceosome function, ultimately paving the way for the development of novel therapeutic strategies targeting RPP40-related pathways.
Product Name:
RPP40 Rabbit Polyclonal Antibody
SKU:
CAB17086
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human RPP40 (NP_001273061).
nucleolar ribonuclease P complex, nucleoplasm, nucleus
Calculated MW:
42kDa
Observed MW:
42kDa
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex.
Purification Method:
Affinity purification
Gene ID:
10799
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RPP40 Rabbit pAb (CAB17086) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
