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RPN1 Polyclonal Antibody

SKU:
CAB24537
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$155 - $431
Frequently bought together:

Description

RPN1 Polyclonal Antibody (CAB24537)

The RPN1 Polyclonal Antibody is a valuable tool for researchers investigating the role of RPN1 in protein quality control and ER-associated degradation pathways. RPN1, also known as Ribophorin 1, is a protein involved in the process of glycoprotein folding and quality control in the endoplasmic reticulum.This polyclonal antibody, generated in rabbits, is highly specific to human RPN1 and is validated for use in various applications, including Western blotting and immunohistochemistry. By targeting the RPN1 protein, researchers can detect and analyze its expression in different cell types, shedding light on its function in protein folding and ER-associated degradation processes.

Understanding the role of RPN1 is essential for unraveling the mechanisms underlying protein quality control and maintaining cellular homeostasis. Dysregulation of RPN1 has been linked to various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic interventions. By utilizing the RPN1 Polyclonal Antibody in their research, scientists can gain valuable insights into the pathophysiology of these conditions and potentially develop novel treatments targeting RPN1-mediated pathways.

Product Name:RPN1 Polyclonal Antibody
Product Code:CAB24537
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:SK-OV-3, Hep G2, BxPC-3, Mouse liver, Rat liver
Cellular Location:Endoplasmic reticulum membrane, Melanosome, Single-pass type I membrane protein

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-350 of human RPN1 (NP_002941.1).
Sequence:GSASS EAPPL INEDV KRTVD LSSHL AKVTA EVVLA HLGGG STSRA TSFLL ALEPE LEARL AHLGV QVKGE DEEEN NLEVR ETKIK GKSGR FFTVK LPVAL DPGAK ISVIV ETVYT HVLHP YPTQI TQSEK QFVVF EGNHY FYSPY PTKTQ TMRVK LASRN VESYT KLGNP TRSED LLDYG PFRDV PAYSQ DTFKV HYENN SPFLT ITSMT RVIEV SHWGN IAVEE NVDLK HTGAV LKGPF SRYDY QRQPD SGISS IRSFK TILPA AAQDV YYRDE IGNVS TSHLL ILDDS VEMEI RPRFP LFGGW KTHYI VGYNL PSYEY LYNLG DQYA
Synonyms:RPN1, OST1, RBPH1, ribophorin I
Calculated MW:68kDa
Observed MW:68kDa

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