The RPLP1 Polyclonal Antibody (CAB6725) is specially developed for research involving RPLP1, a ribosomal protein involved in protein synthesis and cell growth. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the RPLP1 protein, this antibody allows for the detection and analysis of RPLP1 in various cell types, making it an ideal tool for studies in molecular biology and cancer research.RPLP1, a key component of the ribosome, plays a crucial role in the translation of genetic information into proteins.
Dysregulation of RPLP1 has been associated with various diseases, making it a potential target for therapeutic interventions. Research on RPLP1 can provide insights into the mechanisms underlying diseases such as cancer, neurodegenerative disorders, and metabolic conditions. Understanding the functions of RPLP1 is essential for the development of novel treatment strategies targeting these diseases.
Product Name:
RPLP1 Rabbit Polyclonal Antibody
SKU:
CAB6725
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat,Zebrafish
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human RPLP1 (NP_000994.1).
Sequence:
MASV SELA CIYS ALIL HDDE VTVT EDKI NALI KAAG VNVE PFWP GLFA KALA NVNI GSLI CNVG AGGP APAA GAAP AGGP APST AAAP AEEK KVEA KKEE SEES DDDM GFGL FD
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Purification Method:
Affinity purification
Gene ID:
6176
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using RPLP1 Rabbit pAb (CAB6725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
