The RPL22 Polyclonal Antibody (CAB9202) is a crucial tool for researchers studying RPL22, a ribosomal protein involved in protein synthesis and cell growth. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the RPL22 protein, this antibody enables the detection and analysis of RPL22 in various cell types, making it an essential resource for studies in molecular biology and cancer research.RPL22 is a key player in ribosome biogenesis and translation, making it a target of interest for researchers studying the mechanisms of protein synthesis and cell proliferation.
Dysregulation of RPL22 has been linked to various diseases, including cancer, making it a potential therapeutic target for developing novel treatments. By gaining insights into the function of RPL22, researchers can uncover new avenues for therapeutic interventions and further our understanding of cellular processes related to disease pathology.
Product Name:
[KO Validated] RPL22 Rabbit Polyclonal Antibody
SKU:
CAB9202
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of human RPL22 (NP_000974.1).
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.
Purification Method:
Affinity purification
Gene ID:
6146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] RPL22 Rabbit pAb (CAB9202) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
